AG Scientific/(R,S)-Rolipram, Inhibitor of PDE IV/5 mg/41.66,AG Scientific,,AG Scientific,agscientific,AG-scientific,中国agscientific公司 AG-scientific BESTATIN HCl,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：AG Scientific/(R,S)-Rolipram, Inhibitor of PDE IV/5 mg/41.66

产品编号：41.66

市场价：¥0.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>单克隆抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： AG Scientific

公司：AG Scientific, Inc.,

公司分类：

商品介绍

MoreInformation

AlternateName/Synonyms

ZK-62711

SKU

R-1012

CAS#

61413-54-5

ChemicalName

4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

ChemicalFormula

C₁₆H₂₁NO₃

MolecularWeight

275.4Da

Appearance

Whitesolid

Purity

≥98%

Solubility

SolubleinWater

MeltingPoint

132°C

Preparation

N/A

StorageTemp

4°C,desiccated

THERAPEUTICAREA

NeurodegenrativeDiseases

USE

Rolipramisaselective,cell-permeableinhibitorofcAMP-specificPDE(phosphodiesterase)(PDE4,IC50=1μM).ThiscompoundhasbeenshowntoinhibitPDE4activityinhumancavernosaltissue,whichinterruptsthesignaltransductionpathwayoferectileresponse.RoliprampromotesapoptosisinHL60cellsthroughacAMP-independentmechanismandhasbeenshowntoenhanceneuronalsurvival.RolipramisaninhibitorofPDE4A1andPDE4B.

MerckIndex

13.8332.2001

MDLNUMBER

MFCD00270906

CHEMACX

X1038250-2

INCHI

InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

SMILES

COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3

RTECS

UY5749237

Handling

FurtherprocessingofsolidmaterialsmayresultintheformationofcombustIBLedusts.Thepotentialforcombustibledustformationshouldbetakenintoconsiderationbeforeadditionalprocessingoccurs.Provideappropriateexhaustventilationatplaceswheredustisformed.

Citations

BEHAVIORAL/SYSTEMS/COGNITIVE:Phosphodiesterase-4DKnock-OutandRNAInterference-MediatedKnock-DownEnhanceMemoryandIncreaseHippocampalNeurogenesisviaIncreasedcAMPSignalingYun-FengLi,Yu-FangCheng,YingHuang,MarcoConti,StevenP.Wilson,JamesM.O"Donnell,andHan-TingZhangJ.Neurosci.,Jan2011;31:172-183.

Citations_Hyperlink

http://www.jneurosci.org/cgi/reprint/31/1/172

MSDs1

R-1012,Rolipram,SDS,diamondformat.pdf

CertificateofAnalysis1

R-1012,F1254E.pdf

CertificateofAnalysis2

R-1012,F1254D.pdf

CertificateofAnalysis3

R-1012,F1254C.pdf

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