Stauprimideisasemi-syntheticanalogueofthestaurosporinefamilyofindolocarbazoles.Stauprimidewasfirstpublishedin1994aspartofanextensivestructure-activityinvestigationtoimprovetheselectiveinhibitionofproteinkinaseCasapotentialantitumoragent.Morerecently,stauprimidehasbeenshowntoincreasetheefficiencyofthedirecteddifferentiationofmouseandhumanembryonicstemcellsinsynergywithdefinedextracellularsignallingcues.StauprimideinteractswithNME2(PUF)transcriptionfactortodown-regulatec-Mycexpression,leADIngtodifferentiationofstemcells.
Synonyms | N-Benzoyl-7-oxostaurosporine | |||
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Product# | S-2092 | |||
CAS# | 154589-96-5 | |||
ChemicalName | N-((5S,6R,7R,9R)-6-METHOXY-5-METHYL-14,16-DIOXO-5,6,7,8,9,14,15,16-OCTAHYDRO-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-7-YL)-N-METHYLBENZAMIDE | |||
Formula | C35H28N4O5 | |||
MW | 584.6 | |||
Appearance | YellowOrangeSolid | |||
Purity | 98%byTLC | |||
Solubility | Solubleinmethanol,ethanol,DMForDMSO | |||
BoilingPoint | 145°C | |||
StorageTemp | -20°C | |||
TherapeuticArea | OncologicalDisorders | |||
Use | StauprimideinhibitsthenuclearlocalizationofNME2,blockinganddownregulatingc-Mycexpressionincertaincancers |
MDLNumber | MFCD14635443 | |||
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ChemACX | X1763223-8 | |||
InChI | InChI=1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1 | |||
SMILES | C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC |
产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
AG Scientific/Proteinase K/500 mg/199.99 | 199.99 | AG Scientific, Inc. | 蛋白酶类 | 0.00 | AG Scientific/Proteinase K/50 mg/39.99 | 39.99 | AG Scientific, Inc. | 其他试剂 | 0.00 | AG Scientific/Proteinase K/100 mg/59.99 | 59.99 | AG Scientific, Inc. | 单克隆抗体 | 0.00 | AG Scientific/Proteinase K (Recombinant), Molecular/PCR Grade/1 g/537.62 | 537.62 | AG Scientific, Inc. | 琼脂糖 | 0.00 | AG Scientific/Proteinase K Solution (20 mg/mL)/5 ml/123.29 | 123.29 | AG Scientific, Inc. | 刺激/抑制试剂 | 0.00 |