MitomycinCisproducedbyastrainofactinomyces, Streptomycescaespitosus.Itcontainsthreeanticancermoieties,quinine,urethane,andaziridinegroups.Itisusedtogeneratemitoticallyinactivefeedercellsincellculturesystems,suchasthemitoticallyinactivefibroblastsusedinembryonicstemcellsystems.
Thisproductisan alkylatingagent thatspecificallytargetstheguaninenucleosidesequence5′-CpG-3′.ItinhibitsDNAsynthesisbycovalentlyreactingwithDNA,formingcrosslinksbetweencomplementarystrandsofDNA.ThisinteractionpreventsseparationofcomplementaryDNAstrands,inhibitingDNAreplication.
MitomycinChasstrong antitumoractivity,especiallyagainstEhrlichascitestumorcells,andstrongbactericidalactionagainstgram-positiveandgram-negativebacteria. MitomycincroleinpluripotentstemcellsresearchexpandsintotheCRISPR/Cas9revolutiontopermitefficientgenecorrection.
AdditionalInformation
| Synonyms | MMC,Mutamycin,Ametycin,Mitocin-C | |||
|---|---|---|---|---|
| Product# | M-1108 | |||
| CAS# | 50-07-7 | |||
| ChemicalName | [(1AS,8S,8AR,8BS)-6-AMINO-8A-METHOXY-5-METHYL-4,7-DIOXO-1,1A,2,4,7,8,8A,8B-OCTAHYDROAZIRENO[2",3":3,4]PYRROLO[1,2-A]INDOL-8-YL]METHYLCARBAMATE | |||
| Formula | C15H18N4O5 | |||
| MW | 334.3 | |||
| Appearance | Blue-VioletCrystals | |||
| Purity | 98% | |||
| Solubility | Solubleinwater(100mg/mlat25°C),ethanol(50mM),methanol(5mg/ml),DMSO(100mM),andDMF | |||
| BoilingPoint | 581.8±50.0°Cat760mmHg | |||
| StorageTemp | -20°C | |||
| TherapeuticArea | OncologicalDisorders | |||
| Use | ADNAcrosslinkingagentthatinhibitsDNAsynthesisandinducesapoptosisinavarietyofcellsuseincancer |
| MerckIndex | 13.6236[p.2001 | |||
|---|---|---|---|---|
| MDLNumber | MFCD00078109 | |||
| ChemACX | X1004059-0 | |||
| InChI | InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1 | |||
| SMILES | CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N |
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| AG Scientific/Proteinase K/500 mg/199.99 | 199.99 | AG Scientific, Inc. | 蛋白酶类 | 0.00 | AG Scientific/Proteinase K/50 mg/39.99 | 39.99 | AG Scientific, Inc. | 其他试剂 | 0.00 | AG Scientific/Proteinase K/100 mg/59.99 | 59.99 | AG Scientific, Inc. | 单克隆抗体 | 0.00 | AG Scientific/Proteinase K (Recombinant), Molecular/PCR Grade/1 g/537.62 | 537.62 | AG Scientific, Inc. | 琼脂糖 | 0.00 | AG Scientific/Proteinase K Solution (20 mg/mL)/5 ml/123.29 | 123.29 | AG Scientific, Inc. | 刺激/抑制试剂 | 0.00 |
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