RNasestandsforRibonucleasewhichisaRNAdigestingenzyme.RNaseconsistsof124aminoacidsinonepolypeptidechainwith4disulphidelinkages. Ribonucleasescanbedividedinto Endoribonucleases and Exoribonucleases. RNaseshaveimportantrolesinRNAdegradationandturnoverinallorganisms. RibonucleaseenzymecanunwindtheRNAhelixbycomplexingwithsingle-strandedRNA.RNaseAisanendoribonucleasewithfunctionsinRNAmetabolismandregulationofgeneexpression. Itwasfoundtoplayrolesindiseasessuchasautoimmunediseases,renalinsufficienciesandpancreasdisorder. Morerecently,anantitumoractivitywasalsoreportedforanRNaseAwithcytotoxicandcytostaticproperties. ThemembersofRNaseAsuperfamilyarewidelyexpressedandpresentinserumandtissuesofmammals. Theribonucleolyticactivityinthepancreasofruminantsisparticularlyhigh,perhapstodigestthelargeamountofRNAproducedbystomachmicroorganisms.
Applications:
TheenzymecanbeusedtohydrolyzeRNAfromproteinsamples.ItiscompatIBLeforuseinRNaseprotectionassays,toremoveunspecificallyboundRNA,intheanalysisofRNAsequences,tohydrolyzeRNAcontainedinproteinsamples,andinthepurificationofDNA.
AdditionalInformation
| Synonyms | bovinepancreaticribonucleaseA,RNaseAEC3.1.27.5 | |||
|---|---|---|---|---|
| Product# | R-2000 | |||
| CAS# | 9001-99-4 | |||
| ChemicalName | RIBONUCLEATE3"-PYRIMIDINOOLIGONUCLEOTIDOHYDROLASE |
| MDLNumber | MFCD00132181 | |||
|---|---|---|---|---|
| ChemACX | X1037961-6 |
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| AG Scientific/Proteinase K/500 mg/199.99 | 199.99 | AG Scientific, Inc. | 蛋白酶类 | 0.00 | AG Scientific/Proteinase K/50 mg/39.99 | 39.99 | AG Scientific, Inc. | 其他试剂 | 0.00 | AG Scientific/Proteinase K/100 mg/59.99 | 59.99 | AG Scientific, Inc. | 单克隆抗体 | 0.00 | AG Scientific/Proteinase K (Recombinant), Molecular/PCR Grade/1 g/537.62 | 537.62 | AG Scientific, Inc. | 琼脂糖 | 0.00 | AG Scientific/Proteinase K Solution (20 mg/mL)/5 ml/123.29 | 123.29 | AG Scientific, Inc. | 刺激/抑制试剂 | 0.00 |
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