HygromycinBisanaminoglycosideantibioticisolatedfrom Streptomyceshygroscopicus.Itiscommonlyusedtostudyproteinsynthesis.Asidefromitsefficacyagainstbacteria,fungi,andhighereukaryoticcells,hygromycinBisalsoanantiviralagentinhibitingtranslationuponselectivelyenteringcellsmadepermeableduetoviralinfection.Itworksasastandardselectionantibioticingeneexperiments,especiallyforthe selectionofhygromycinresistancegenetransformedcells.Aminoglycosideantibioticsarecomposedofaminogroupsattachedtoglycosides.Theybindthe30sribosomalsubunit,causingmisreADIngofthemRNAsequenceandinhibitionoftranslocation.Consequently,proteinsynthesisisinhibited.
Antibioticsareoftenusedinclinicalin-vitrotestsknownasantimicrobialsusceptibilitytestsorASTstodeterminetheirefficacyagainstcertainbacterialspecies. Hygromycin"s longstandingapplicationasageneselectionantibiotic hasapowerfulnewroleinGenomeeditingutilizingtheCRISPR/Cas9system.
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AdditionalInformation
| Product# | H-1012-SOLID | |||
|---|---|---|---|---|
| CAS# | 31282-04-9 | |||
| ChemicalName | O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine | |||
| Formula | C20H37N3O13 | |||
| MW | 527.53 | |||
| Appearance | SolidPowder | |||
| Purity | >95% | |||
| Solubility | SolubleinWater | |||
| BoilingPoint | 897.6±65.0°Cat760mmHg | |||
| Preparation | Workingsolutions(<2mg> | |||
| StorageTemp | +4°C | |||
| TherapeuticArea | InfectiousDiseases | |||
| Use | HygromycinBisanantibioticproducedbythebacteriumStreptomyceshygroscopicus.Itisanaminoglycosidethatkillsbacteriaandfungi. |
| MerckIndex | 13.4878 | |||
|---|---|---|---|---|
| MDLNumber | MFCD06795479 | |||
| ChemACX | X1009739-3 | |||
| InChI | InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1 | |||
| SMILES | CN[C@H]1C[C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2[C@@H]3[C@H]([C@H]([C@H](O2)CO)O)OC4(O3)[C@@H]([C@@H]([C@H]([C@H](O4)[C@H](CO)N)O)O)O)O)N |
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| AG Scientific/Proteinase K/500 mg/199.99 | 199.99 | AG Scientific, Inc. | 蛋白酶类 | 0.00 | AG Scientific/Proteinase K/50 mg/39.99 | 39.99 | AG Scientific, Inc. | 其他试剂 | 0.00 | AG Scientific/Proteinase K/100 mg/59.99 | 59.99 | AG Scientific, Inc. | 单克隆抗体 | 0.00 | AG Scientific/Proteinase K (Recombinant), Molecular/PCR Grade/1 g/537.62 | 537.62 | AG Scientific, Inc. | 琼脂糖 | 0.00 | AG Scientific/Proteinase K Solution (20 mg/mL)/5 ml/123.29 | 123.29 | AG Scientific, Inc. | 刺激/抑制试剂 | 0.00 |
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