Curvularinisa12-memberedmacrocycliclactoneincorporatingaresorcinylmoiety,producedbyanumberoffungalspeciesincludingCurvularia,PenicilliumandAlternaria.CurvularinexhibitsadistinctlydifferentBIOLOGicalprofiletothestructurallysimilarresorcylicacidlactonessuchasthezearalenones,rADIcicolandLLZ1640-2.Curvularininhibitscelldivisionbydisruptingmitoticspindleformationandisknowntobephytotoxic.Morerecentinvestigationshaveshownthatcurvularinisahighlyselectivetranscription-basedinhibitorofiNOS-dependentNOproduction,actingontheJanustyrosinekinase-STATpathway.ThisactionoffersanapproachtothedevelopmentofdrugsinhibitingiNOSoverproductionassociatedwithNOpathophysiology.
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Synonyms | S-Curvularin,NSC166071 | |||
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Product# | C-2675 | |||
CAS# | 10140-70-2 | |||
Formula | C16H20O5 | |||
MW | 292.3 | |||
Appearance | Whitesolid | |||
Purity | >99%byHPLC | |||
Solubility | Solubleinmethanol,dioxane,pyridine | |||
BoilingPoint | 557.0±29.0°Cat760mmHg | |||
StorageTemp | -20°C | |||
Use | ApotentantifungalandmycotoxinthatalsoinhibitsNOproduction |
MDLNumber | MFCD09752718 | |||
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InChI | InChI=1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1 | |||
SMILES | C[C@H]1CCCCCC(=O)c2c(cc(cc2O)O)CC(=O)O1 |
产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
AG Scientific/Proteinase K/500 mg/199.99 | 199.99 | AG Scientific, Inc. | 蛋白酶类 | 0.00 | AG Scientific/Proteinase K/50 mg/39.99 | 39.99 | AG Scientific, Inc. | 其他试剂 | 0.00 | AG Scientific/Proteinase K/100 mg/59.99 | 59.99 | AG Scientific, Inc. | 单克隆抗体 | 0.00 | AG Scientific/Proteinase K (Recombinant), Molecular/PCR Grade/1 g/537.62 | 537.62 | AG Scientific, Inc. | 琼脂糖 | 0.00 | AG Scientific/Proteinase K Solution (20 mg/mL)/5 ml/123.29 | 123.29 | AG Scientific, Inc. | 刺激/抑制试剂 | 0.00 |