GeldanamycinisabenzoquinoneansamycinantibioticwhichbindstoHsp90(HeatShockProtein90)andaltersitfunction.HSP90clientproteinsplayimportantrolesintheregulationofthecellcycle,cellgrowth,cellsurvival,apoptosis,andoncogenesis.Cdc28providesamolecularlinkbetweenHsp90,morphogenesis,andcellcycleprogressioninCandidaalbicans.EpidermalGrowthFactorReceptorswithTyrosineKinaseDomainMutationsExhibitReducedCblAssociation,PoorUbiquitylation,andDown-regulationbutAreEfficientlyInternalized.InhibitionofHSP90inTrypanosomacruziInducesaStressResponsebutNoStageDifferentiation,RoleoftheHeatShockProtein90inImmuneResponseStimulationbyBacterialDNAandSyntheticOligonucleotides.
Synonyms | GA | |||
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Product# | G-1047 | |||
CAS# | 30562-34-6 | |||
ChemicalName | [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-HYDROXY-5,11,21-TRIMETHOXY-3,7,9,15-TETRAMETHYL-16,20,22-TRIOXO-17-AZABICYCLO[16.3.1]DOCOSA-1(21),8,12,14,18-PENTAEN-10-YL]CARBAMATE | |||
Formula | C29H40N2O9 | |||
MW | 560.6 | |||
Appearance | YellowSolid | |||
Purity | 98% | |||
Solubility | SolubleinDMSO | |||
BoilingPoint | 783.9±60.0°Cat760mmHg | |||
StorageTemp | -20°C | |||
TherapeuticArea | OncologicalDisorders | |||
Use | GeldanamycinAnalogueinTreatingPatientsWithColonCancer |
MDLNumber | MFCD00274570 | |||
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ChemACX | X1035747-8 | |||
InChI | InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1 | |||
SMILES | C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)C)C)O)OC |
产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
AG Scientific/Proteinase K/500 mg/199.99 | 199.99 | AG Scientific, Inc. | 蛋白酶类 | 0.00 | AG Scientific/Proteinase K/50 mg/39.99 | 39.99 | AG Scientific, Inc. | 其他试剂 | 0.00 | AG Scientific/Proteinase K/100 mg/59.99 | 59.99 | AG Scientific, Inc. | 单克隆抗体 | 0.00 | AG Scientific/Proteinase K (Recombinant), Molecular/PCR Grade/1 g/537.62 | 537.62 | AG Scientific, Inc. | 琼脂糖 | 0.00 | AG Scientific/Proteinase K Solution (20 mg/mL)/5 ml/123.29 | 123.29 | AG Scientific, Inc. | 刺激/抑制试剂 | 0.00 |