AG Scientific/Thapsigargin, ER stress inducer/T-1014/10 mg,AG Scientific,,AG Scientific,agscientific,AG-scientific,agscientific厂家直采，平行进口 AG-scientific高纯度两性离子,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：AG Scientific/Thapsigargin, ER stress inducer/T-1014/10 mg

产品编号：T-1014-10mg

市场价：¥7661.80

场地：美国(厂家直采)

产品分类：细胞相关>细胞培养>刺激/抑制试剂>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$383.09

品牌： AG Scientific

公司：AG Scientific, Inc.,

公司分类：

商品介绍

Thapsigargin isaspecificinhibitorofthesarcoplasmic/endoplasmicreticulum Ca2+-ATPase (SERCA). Thapsigargin increasescytosolic calcium levelsthroughreleasefromintracellular calcium stores.DepletionofERcalciumstoresleadstoCa²⁺ influxviaactivationof store(voltage)-operatedcalciumchannels inthe plasmamembrane,mediatingnumerousphysiologicalfunctions,including exocytosis, chemotaxis,transcription, celldivision,and apoptosis. Therearepreclinicalindicationsthatthedrugmayhave anticancer potential.

Arecentpaperstatesthapsigarginisamoleculethatindirectly&robustlyinhibitsnonsense-mediatedRNAdecay(NMD)¹byDr.Zheng,UCRinRNA(volume23,No.3, March2017).HestatestheyhavedevelopedamethodthatdetectsNMDefficiencyinsidethecell.

AdditionalInformation

Synonyms	thaps,tg
Product#	T-1014
CAS#	67526-95-8
ChemicalName	[(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-ACETYLOXY-4-BUTANOYLOXY-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(Z)-2-METHYLBUT-2-ENOYL]OXY-2-OXO-4,5,6A,7,8,9B-HEXAHYDROAZULENO[4,5-B]FURAN-7-YL]OCTANOATE
Formula	C₃₄H₅₀O₁₂
MW	650.8
Appearance	ClearColorlessFilm
Purity	98%
Solubility	DMSO(~100mg/ml)
BoilingPoint	691.9±55.0°Cat760mmHg
StorageTemp	-20°C
TherapeuticArea	OncologicalDisorders
Use	ItisatumorpromoterandinducesthereleaseofintracellularstoredCa2+withouthydrolysisofinositolphospholipidsviainhibitionofthesarco/endoplasmicreticulumCa2+-ATPase

品牌介绍

AG Scientific常用产品报价单

MerckIndex	MerckIndex:13.9342
MDLNumber	MFCD00083511
ChemACX	X1096797-0
InChI	InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
SMILES	CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=CC)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O

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