AEBSFisabroadspectrum,watersoluble,irreversIBLeserineproteaseinhibitor.InhibitionconstantsaresimilartothoseofPMSFandDFP.AEBSFhasbeenshowntoinhibittrypsin,chymotrypsin,plasminkallikreinandthrombin.AsanalternativetoPMSFandDFP,AEBSFofferslowertoxicity,improvedsolubilityinwaterandimprovedstABIlityinaqueoussolutions.Ithasbeenshowntoinhibittheconstitutiveproductionofbetaamyloid(Abeta)infivedifferenthumancelllines,bothneuralandnon-neural.
AEBSFalsoinhibitsactivationofTGFβ(transforminggrowthfactorbeta),moderatelyinhibitsDipeptidylpeptidaseIV(DPPIV)andactivatesJNKandp38MAPkinases.AEBSFisab-secretaseinhibitorthathasbeenshowntoinhibitbetaamyloidpeptideproductionandenhanceAPP(amyloidprecursorprotein)secretioninseveralcelllinesatmillimolarconcentrations.
AdditionalInformation
| Synonyms | Pefabloc | |||
|---|---|---|---|---|
| Product# | A-1018 | |||
| CAS# | 30827-99-7 | |||
| ChemicalName | 4-(2-Aminoethyl)-bezenesulfonylfluoride.HCl | |||
| Formula | C8H10FNO2S.HCl | |||
| MW | 239.5 | |||
| Appearance | Off-WhiteSolid | |||
| Purity | 98% | |||
| Solubility | DMSO,Methanol:Clearpurplesolutionat10mg/ml. | |||
| MeltingPoint | 182-184°C | |||
| StorageTemp | -20°C | |||
| Use | AEBSFisabroadspectrum,watersoluble,irreversibleserineproteaseinhibitor |
| MDLNumber | MFCD00132962 | |||
|---|---|---|---|---|
| ChemACX | X1086833-8 | |||
| InChI | InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H | |||
| SMILES | c1cc(ccc1CCN)S(=O)(=O)F.Cl |
| 产品名 | 货号 | 公司分类 | 商城分类 | 美金价 |
| AG Scientific/Proteinase K/500 mg/199.99 | 199.99 | AG Scientific, Inc. | 蛋白酶类 | 0.00 | AG Scientific/Proteinase K/50 mg/39.99 | 39.99 | AG Scientific, Inc. | 其他试剂 | 0.00 | AG Scientific/Proteinase K/100 mg/59.99 | 59.99 | AG Scientific, Inc. | 单克隆抗体 | 0.00 | AG Scientific/Proteinase K (Recombinant), Molecular/PCR Grade/1 g/537.62 | 537.62 | AG Scientific, Inc. | 琼脂糖 | 0.00 | AG Scientific/Proteinase K Solution (20 mg/mL)/5 ml/123.29 | 123.29 | AG Scientific, Inc. | 刺激/抑制试剂 | 0.00 |
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